
Michelle Obama, giving the first keynote address of the party's four-day convention in Denver, said he would make "an extraordinary president".
Senator Edward Kennedy, undergoing treatment for brain cancer, also lauded Mr Obama, saying he offered "new hope".
House Speaker Nancy Pelosi spoke of a defining moment in history for the US.
Praising Mr Obama's "bold" vision for the nation's future, Mrs Pelosi described him as "honouring American values, a belief in personal responsibility, in community, in hard work".
Mr Obama, 47, will formally accept the party's nomination when he addresses a crowd of 80,000 at a sports stadium on Thursday night, fresh from touring electoral battlegrounds.
The first African-American to be nominated as a US presidential candidate, he will stand against Republican John McCain in the 4 November ballot.
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